Hashimoto's thyroiditis is the most common autoimmune disease and leads to hypothyroidism. About 10-15% of patients with Hashimoto's thyroiditis report persistent symptoms despite adequate thyroid hormone replacement.

Typical symptoms are cognitive abnormalities, especially in the related areas of memory and executive functions, pronounced fatigue and mood swings or depressive moods. This so-called "brain fog" impairs the quality of life and leads to reduced treatment satisfaction, with the result that many patients seek alternative treatment options.

The aim of the EMIRA study is to develop a digital health application (app) that addresses these brain fog symptoms. In eight modules, based on cognitive rehabilitation and behavioural therapy, patients are taught knowledge, strategies and skills that are supportive in coping with the ongoing symptoms of brain fog. These modules include areas such as memory, physical activity and sleep. The effectiveness of this application is now being tested in a randomised controlled trial.